TB Centre Seminar Series: Urine-based diagnostics and mortality in HIV-associated TB


TB Seminar Series: Pre-Viva
Urine-based diagnostics and mortality in HIV-associated TB
Dr. Ankur Gupta-Wright

Date: Thursday 6th December
Venue: Jerry Morris B, Tavistock Place
Time: 12:45 – 13:45

This PhD aimed to understand if positive urine-diagnostic tests in hospitalised patients with HIV and TB disease were associated with mortality, be used as a prognostic marker for identifying patients with poor outcomes, and could identify patients with impairment of immune responses. Methods included a systematic review and meta-analysis, a prospective clinical cohort study. Data presented could inform the choice and nature of interventions to reduce the high mortality of HIV/TB, including better identification and management of ART failure, therapies to address TB-related immune dysfunction, and improved supportive care and prevention and treatment of co-morbidities.

Bio: Dr. Ankur Gupta-Wright is a clinical research fellow and infectious disease registrar who was based in Southern Malawi from 2015-2018. He undertook his PhD whilst running a clinical trial on TB screening in hopsitalised HIV-positive patients using urine-based rapid diagnostics.